Chow Lab @ Penn Bioengineering



  1. Sheehan, M.M., Mancini, J.A., Magaraci, M.S., Kuznetsov, I.A., Hannanta-Anan, P., Kodali, G., Moser, C.C., Dutton, P.L., and Chow, B.Y. Mammalian cell-expressible de novo fluorescent proteins, Nature Chemical Biology, under revision

  2. Magaraci, M.S., Bermudez, J., Yogish, D., Pak, D., Mollov, V., Tycko, J., Issadore, D., Mannickarottu, S.G., and Chow, B.Y. Toolbox for exploring modular gene regulation in synthetic biology training, ACS Synthetic Biology (2016) 5, 781-785. [PDF]

  3. Hannanta-anan, P. and Chow, B.Y. Optogenetic control of calcium oscillation waveform defines NFAT as an integrator of calcium load, Cell Systems (2016), 2, 283-288 [PDF] [Viewpoint]

  4. Glantz, S.T., Carpenter, E.J., Melkonian, M., Gardner, K.H., Boyden E.S., Wong, G.K-S., and Chow, B.Y. Functional and topological diversity of LOV domain photoreceptors, Proceedings of the National Academy of Sciences USA (2016) 113, E1442-E1451 (direct submission) [PDF]

  5. Chuong, A. S., Miri, M. L.*, Busskamp, V.*, Matthews, G.A.C.*, Acker, L.C.*, Soresnsen, A.T., Young, A., Klapoetke, N. C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, R., Cardin, J.A., Boyden, E. S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nature Neuroscience (2014) 17: 1123-1129. (* equal contribution) [PDF]

  6. Klapoetke, N. C., Murata, Y., Kim S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., Wang, J., Xie, Y., Yan, Z., Zhang, Y., Chow, B.Y., Surek, B., Melkonian, M., Jayaraman, V., Constantine-Paton, M., Wong, G. K.*, Boyden, E. S.* Independent optical excitation of distinct neural populations, Nature Methods (2014) 11:338–346.[PDF]

  7. Paul, S.M., Doherty, J.J., Robichaud, A.J., Belfort, G.M., Chow, B.Y., Hammond, R.S., Crawford, D.C., Lisenbardt, A.J., Shu, H-J., Izumi, Y., Mennerick, S.J., Zorumski, C.Z., The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors, The Journal of Neuroscience (2013), 33,17290 –17300 [PDF]

  8. Chow, B.Y. and Boyden, E.S. Optogenetics in translational medicine, Science Translational Medicine, (2013) 5, 177ps5 [PDF]

  9. Kodandaramariah, S., Franzesi, G.T., Chow, B.Y., Boyden, E.S., Forest, C.R. Automated whole-cell patch clamp electrophysiology in vivo, (2012) Nature Methods, 9, 585-590 [PDF]

  10. Chow, B.Y.*, Han, X.*, and Boyden, E.S. Genetically encoded molecular tools for light-driven silencing of specific neurons Progress in Brain Research (2012), 196, 49-61 (* equal contributions) [PDF]

  11. Chow, B.Y. and Boyden, E.S., Synthetic Physiology, Science (2011) 332, 1508-1509 [PDF]

  12. Joo, J., Chow, B.Y.*, Prakash, M., Boyden, E.S., and Jacobson, J.M. Face-selective electrostatic control of hydrothermal zinc oxide nanowire synthesis, Nature Materials (2011), 10, 596-601 (*corresponding author) [PDF]

  13. Han, X.*, Chow, B.Y.*, Zhou, H., Klapoetke, N.C., Chuong, A.S., Rajimehr, R., Yang, A., Winkle, J., Desimone, R., and Boyden, E.S , A High-light sensitivity optical neural silencer: Development and application to optogenetic control of nonhuman primate cortex, Frontiers in Systems Neuroscience (2011) 5:18 (*equal contributions) [PDF]

  14. Chow, B.Y.*, Chuong, A.S.*, Klapoetke, N.C.*, and Boyden, E.S. Synthetic physiology: Strategies for adapting tools from nature for genetically targeted control of fast biological processes, Methods in Enzymology (2011), 497, 425-443 (*equal contributions) [PDF]

  15. Chow, B.Y.*, Han, X.*, Dobry, A.S., Qian, X., Chuong, A.S., Li, M., Henninger, M.A., Belfort, G.M., Lin, Y., Monahan, P.E., and Boyden, E.S., High-performance genetically targetable optical neural silencing via light-driven proton pumps. Nature (2010) 463, 98-102 (* equal contributions) [PDF]

  16. Chow, B.Y., Emig, C.J., and Jacobson, J.M., Photoelectrochemical synthesis of DNA microarrays, Proceedings of the National Academy of Sciences USA (2009) 106, 15219-15224 (direct submission) [PDF]

  17. Joo, J., Chow, B.Y., and Jacobson, J.M., Nanoscale patterning on insulating substrates by critical energy electron beam lithography, NanoLetters (2006) 6, 2021-2025 [PDF]

  18. Mosley, D.W., Chow, B.Y., and Jacobson, J.M., Solid-state bonding technique for template-stripped ultraflat gold substrates Langmuir (2006) 22, 2437-2440 [PDF]

  19. Chow, B.Y., Mosley, D.W., and Jacobson, J.M., Perfecting imperfect ‘monolayers’: Removal of siloxane multilayers by CO2 snow treatment Langmuir (2005) 4782-4785 [PDF]

Refereed Proceedings

  1. Tycko, J., Cabrera, D., Fields, D., Kaptur, B., Charawi, M., Glantz, S., Magaraci, M.S., Veerakumar, A., Miller, J.S., and Chow, B.Y. Development of a single-plasmid system for screening site-specific DNA methylases Penn Science (2014) 24–27 [Note: undergraduate iGEM publication] [PDF]

  2. Chow, B.Y., Mosley, D.W., and Jacobson, J.M., Patterning DNA tiles into arbitrary 2-dimensional shapes, in Proceedings of the Third Annual Conference on Foundations of Nanoscience (2006) Reif, J.H. ed., Sciencetechnica

Books/Chapters and Byline Articles

  1. Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2012) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, p. 305-338, Neuronal Network Analysis: Concepts and Experimental Approaches, edited by Tommaso Fellin and Michael Halassa, Neuromethods Series Volume 67, Humana Press.

  2. Chow, B.Y., Han. X., Bernstein, J.G., Monahan, P.E., and Boyden, E.S., Light-activated channels and pumps for optogenetic control of neural activity in Photosensitive Molecules for Controlling Biological Function, Chambers, J. and Kramer, R. eds. Neuromethods Series Volume 55, Part 2, Chapter 6: 99-132 (2011) Humana Press

  3. Boyden, E. S. and Chow, B. Y. (2010) Defining An Algorithm For Inventing From Nature Column, Technology Review. 1/19/2010 [PDF]

Patents (Issued Only)

  1. Automated Cell Patch Clamping Method and Apparatus - Notice of allowance - Priority 2012
  2. Auto-Patch: A Robot for Automated Whole Cell Patch Clamping From Neurons in the Whole Intact Mammalian Brain - US 9498293 - Priority 2011
  3. Red-shifted opsin molecules and uses thereof - US 8957028 - Priority 2010
  4. Identifying new therapeutic agents - US 9428845 - Priority 2010
  5. Methods and apparatus for control of hydrothermal nanowire synthesis - US 8367435 - Priority 2009
  6. Methods for high fidelity production of long nucleic acid molecules - US 9499848 - Priority 2002
  7. Methods for high fidelity production of long nucleic acid molecules with error control - US 8263335 - Priority 2002
  8. Methods for high fidelity production of long nucleic acid molecules - US 8507226 - Priority 2002
  9. Methods for high fidelity production of long nucleic acid molecules - US 8206952 - Priority 2002
  10. Methods for high fidelity production of long nucleic acid molecules - US 7879580 - Priority 2002