Chow Lab @ Penn Bioengineering



  1. Berlew, E.E., Kuznetsov, I.A., Yamada, K. Bugaj, L.J., and Chow, B.Y., Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation, Photochemical and Photobiological Sciences (2019) submitted

  2. Szymula, K.P.*, Magaraci, M.S.*, Patterson, M. Clark, A., Mannickarottu, S.G., and Chow, B.Y., An open-source plate reader, Biochemistry (2019) 58(6), 468-473 (* equal contributions) [PDF] [Github Link] [Cover Art] [Nature feature] [CE&N feature]

  3. Hannanta-anan, P., Glantz, S.T., and Chow, B.Y., Optically inducible membrane recruitment and signaling systems, Current Opinion in Structural Biology (2019) 57, 84-92 [PDF]

  4. Glantz, S.T.*, Berlew, E.E.*, and Chow, B.Y., Synthetic cell-like membrane interfaces for probing dynamic protein-lipid interactions, Methods in Enzymology (2019) 622, 249-270 (* equal contributions) [PDF]

  5. Glantz, S.T., Berlew, E.E., Jayber, Z., Schuster, B.S., Gardner K.H., and Chow, B.Y., Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids, Proceedings of the National Academy of Sciences USA (2018) 115 (33) E7720-E7727 (direct submission) [PDF]

  6. Sheehan, M.M.*, Magaraci, M.S.*, Kuznetsov, I.A.*, Mancini, J.A.*, Kodali, G., Moser, C.C., Dutton, P.L., and Chow, B.Y. Rational construction of compact de novo-designed biliverdin-binding proteins, Biochemistry (2018) 57(49): 6752-6756 (*equal contributions) [PDF]

  7. Hannanta-Anan, P., and Chow, B.Y., Optogenetic inhibition of Gαq signaling reduces calcium oscillation stochasticity, ACS Synthetic Biology (2018) 7(6): 1488–1495 [PDF]

  8. Mancini, J.A., Sheehan, M., Kodali, G., Chow, B.Y., Bryant, D.A., Dutton, P.L., and Moser, C.C. De novo synthetic biliprotein design, assembly and excitation energy transfer, Journal of the Royal Society Interface (2018), 15(141). [PDF]

  9. Magaraci, M.S., Bermudez, J., Yogish, D., Pak, D., Mollov, V., Tycko, J., Issadore, D., Mannickarottu, S.G., and Chow, B.Y. Toolbox for exploring modular gene regulation in synthetic biology training, ACS Synthetic Biology (2016) 5, 781-785. [PDF]

  10. Hannanta-anan, P. and Chow, B.Y. Optogenetic control of calcium oscillation waveform defines NFAT as an integrator of calcium load, Cell Systems (2016), 2, 283-288 [PDF] [Viewpoint]

  11. Glantz, S.T., Carpenter, E.J., Melkonian, M., Gardner, K.H., Boyden E.S., Wong, G.K-S., and Chow, B.Y. Functional and topological diversity of LOV domain photoreceptors, Proceedings of the National Academy of Sciences USA (2016) 113, E1442-E1451 (direct submission) [PDF]

  12. Chuong, A. S., Miri, M. L.*, Busskamp, V.*, Matthews, G.A.C.*, Acker, L.C.*, Soresnsen, A.T., Young, A., Klapoetke, N. C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, R., Cardin, J.A., Boyden, E. S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nature Neuroscience (2014) 17: 1123-1129. (* equal contribution) [PDF]

  13. Klapoetke, N. C., Murata, Y., Kim S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., Wang, J., Xie, Y., Yan, Z., Zhang, Y., Chow, B.Y., Surek, B., Melkonian, M., Jayaraman, V., Constantine-Paton, M., Wong, G. K.*, Boyden, E. S.* Independent optical excitation of distinct neural populations, Nature Methods (2014) 11:338–346.[PDF]

  14. Paul, S.M., Doherty, J.J., Robichaud, A.J., Belfort, G.M., Chow, B.Y., Hammond, R.S., Crawford, D.C., Lisenbardt, A.J., Shu, H-J., Izumi, Y., Mennerick, S.J., Zorumski, C.Z., The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors, The Journal of Neuroscience (2013), 33,17290 –17300 [PDF]

  15. Chow, B.Y. and Boyden, E.S. Optogenetics in translational medicine, Science Translational Medicine, (2013) 5, 177ps5 [PDF]

  16. Kodandaramariah, S., Franzesi, G.T., Chow, B.Y., Boyden, E.S., Forest, C.R. Automated whole-cell patch clamp electrophysiology in vivo, (2012) Nature Methods, 9, 585-590 [PDF]

  17. Chow, B.Y.*, Han, X.*, and Boyden, E.S. Genetically encoded molecular tools for light-driven silencing of specific neurons Progress in Brain Research (2012), 196, 49-61 (* equal contributions) [PDF]

  18. Chow, B.Y. and Boyden, E.S., Synthetic Physiology, Science (2011) 332, 1508-1509 [PDF]

  19. Joo, J., Chow, B.Y.*, Prakash, M., Boyden, E.S., and Jacobson, J.M. Face-selective electrostatic control of hydrothermal zinc oxide nanowire synthesis, Nature Materials (2011), 10, 596-601 (*corresponding author) [PDF]

  20. Han, X.*, Chow, B.Y.*, Zhou, H., Klapoetke, N.C., Chuong, A.S., Rajimehr, R., Yang, A., Winkle, J., Desimone, R., and Boyden, E.S , A High-light sensitivity optical neural silencer: Development and application to optogenetic control of nonhuman primate cortex, Frontiers in Systems Neuroscience (2011) 5:18 (*equal contributions) [PDF]

  21. Chow, B.Y.*, Chuong, A.S.*, Klapoetke, N.C.*, and Boyden, E.S. Synthetic physiology: Strategies for adapting tools from nature for genetically targeted control of fast biological processes, Methods in Enzymology (2011), 497, 425-443 (*equal contributions) [PDF]

  22. Chow, B.Y.*, Han, X.*, Dobry, A.S., Qian, X., Chuong, A.S., Li, M., Henninger, M.A., Belfort, G.M., Lin, Y., Monahan, P.E., and Boyden, E.S., High-performance genetically targetable optical neural silencing via light-driven proton pumps. Nature (2010) 463, 98-102 (* equal contributions) [PDF]

  23. Chow, B.Y., Emig, C.J., and Jacobson, J.M., Photoelectrochemical synthesis of DNA microarrays, Proceedings of the National Academy of Sciences USA (2009) 106, 15219-15224 (direct submission) [PDF]

  24. Joo, J., Chow, B.Y., and Jacobson, J.M., Nanoscale patterning on insulating substrates by critical energy electron beam lithography, NanoLetters (2006) 6, 2021-2025 [PDF]

  25. Mosley, D.W., Chow, B.Y., and Jacobson, J.M., Solid-state bonding technique for template-stripped ultraflat gold substrates Langmuir (2006) 22, 2437-2440 [PDF]

  26. Chow, B.Y., Mosley, D.W., and Jacobson, J.M., Perfecting imperfect ‘monolayers’: Removal of siloxane multilayers by CO2 snow treatment Langmuir (2005) 4782-4785 [PDF]

Refereed Proceedings

  1. Tycko, J., Cabrera, D., Fields, D., Kaptur, B., Charawi, M., Glantz, S., Magaraci, M.S., Veerakumar, A., Miller, J.S., and Chow, B.Y. Development of a single-plasmid system for screening site-specific DNA methylases Penn Science (2014) 24–27 [Note: undergraduate iGEM publication] [PDF]

  2. Chow, B.Y., Mosley, D.W., and Jacobson, J.M., Patterning DNA tiles into arbitrary 2-dimensional shapes, in Proceedings of the Third Annual Conference on Foundations of Nanoscience (2006) Reif, J.H. ed., Sciencetechnica

Books/Chapters and Byline Articles

  1. Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2012) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, p. 305-338, Neuronal Network Analysis: Concepts and Experimental Approaches, edited by Tommaso Fellin and Michael Halassa, Neuromethods Series Volume 67, Humana Press.

  2. Chow, B.Y., Han. X., Bernstein, J.G., Monahan, P.E., and Boyden, E.S., Light-activated channels and pumps for optogenetic control of neural activity in Photosensitive Molecules for Controlling Biological Function, Chambers, J. and Kramer, R. eds. Neuromethods Series Volume 55, Part 2, Chapter 6: 99-132 (2011) Humana Press

  3. Boyden, E. S. and Chow, B. Y. (2010) Defining An Algorithm For Inventing From Nature Column, Technology Review. 1/19/2010 [PDF]

Patents (Issued Only, Listed by Priority Date)

  1. Channelrhodopsins for optical control of cells - US 10472399
  2. Channelrhodopsins for optical control of cells - US 10472398
  3. Blue light-activated ion channel molecules and uses thereof - US 10392426
  4. Automated Cell Patch Clamping Method and Apparatus - US 9668804
  5. Automated Cell Patch Clamping Method and Apparatus - US 9498293
  6. Red-shifted opsin molecules and uses thereof - US 8957028
  7. Identifying new therapeutic agents - US 9428845
  8. Methods and apparatus for control of hydrothermal nanowire synthesis - US 8367435
  9. Methods for high fidelity production of long nucleic acid molecules - US 9499848
  10. Methods for high fidelity production of long nucleic acid molecules with error control - US 8263335
  11. Methods for high fidelity production of long nucleic acid molecules - US 8507226
  12. Methods for high fidelity production of long nucleic acid molecules - US 8206952
  13. Methods for high fidelity production of long nucleic acid molecules - US 7879580